Food folate VS Folic Acid VS Magnafolate
- Aug 22, 2017 -

FOOD FOLATE VS FOLIC ACID VS MAGNAFOLATE™                                                                                                                   

 

 Difference of chemical structure

 

Figure 1: Chemical structure of Food folate, folic acid and Magnafolate™

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 ※ Difference of metabolic mechanism

Both Folic acid and dietary folate need to be converted to the metabolically active 5-methyltetrahydrofolate (5-MTHF) through a multi-steps process where the enzyme methylenetetrahydrofolate reductase (MTHFR) owns a key role. 

While, Magnafolate™ passes the gastric barrier and is absorbed directly. It is effective for folate metabolism disorders as well.

 

Figure 2: Metabolic mechanism

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  Difference of performance

Table1: Dietary folate VS Folic Acid VS Magnafolate

Folate type

Dietary folate

Synthetic folic acid

L-5-Methlyfolate

 Acute toxicity

 N/A

LD50 10mg/kg

Non-C crystal form

C-crystal form Magnafolate    ®

LD50 2000mg/kg 

MTD>15g/kg

Cover up the use of VB12 ?

No

Yes

No

Can it across into the brain?

Yes

NO

Yes

 

Absorption site

Through the    intestinal absorption, do not need to go through the liver, the dosage is    unlimited

liver, the dosage is    limited

Through the    intestinal absorption, do not need to go through the liver, the dosage is    unlimited

Absorption and utilization

After  hydrolysis

Need three
     step enzyme    catalysis

Directly

Genetic abnormality

Effective

Inefficient

Effective

Source

Difficult to obtain

The easiest to obtain

Easy to obtain

Cost

High cost

The lowest cost

Lower cost

Chemical stability

Extreme unstable

Stable

Stable

Reducibility

Strong

N/A

Strong

Dosage

High limit

High limit

Low limit

Side effect

N/A

Causes a decrease in    immunity,
     multiple births,
     leukemia, arthritis,    and certain diseases
     that have not yet    been identified

N/A

Effects
     on the liver

Protects the liver    by protecting GSH activity, but is less affected by fewer amounts

 

Increase liver    burden

 

Protects liver by    protecting GSH activity