Generations of Folate
- Aug 22, 2017 -

GENERATIONS OF FOLATE                                                                                                                                


Both “folic acid” and “folate” are known as Vitamin B9, which is especially important during periods of rapid cell division and growth such as infancy and pregnancy.


With the development of human, folate has been improving from the inactive folic acid to active methylated folate, from the structure of raceme to optical voidness, from the form of amorphous to crystalline.

The commercial folate has been trends to be purer, safer and more stable to satisfy human’s requirement.  


Hence, in broad terms, folate is divided into two generations: the first generation is Inactive folic acid and the second generation is Active folate.


v1st generation – Inactive Folic Acid

Inactive folic acid is the man-made form of folate.

It has been used to fortify foods for years. However, several concerns have been raised regarding its safety and effectiveness. Researchers have shown around 20% people have a genetic variation that prevents them from receiving any benefit from folic acid, or only converting a small amount of folic acid. This variation is known as MTHFR. Further, inactive folic acid has also been found to mask vitamin B-12 deficiency.


v2nd generation – Active Folate


Active folate is also called methylated folate, which has been developing step by step.

In the 1940s-1950s, methyltetrahydrofolate was researched successfully, unlike folic acid, it’s a kind of active folate which does not depend on the invivo transformation system.

In the 1960s, amorphous 6S-5-mehtyltetrahydrofolate raceme was achieved along with double potency.

In the 2000, the crystalline 6S-5-methyltetrahydrofolate salt appeared. The crystalline form solved the instability of amorphous form and has longer validity.

In 2012, Lianyungang Jinkang Hexin Pharmaceutical Co.,Ltd developed a new

great C-effect crystalline 6S-5-methyltetrahydrofolate Calcium patented “Magnafolate-C™”, which enjoys high purity, stability, excellent bioavailability and safety.


Nowdays, C-effect Crystalline L-5-Methyltetrahydrofolate Calcium Salt brings us purer and safer active folate.

It represents the highest level in the 2nd generation.