What’s the difference between L-5-MTHF Ca Crystalline and L-5MTHF Ca amorphous L-5-MTHF Ca has two kinds, one is the crystalline form, the other one is the amorphous form. Crystalline form has higher stability, safety and bioavailability.
The crystalline of L-5-MTHF Ca is synthesized by reduction of folic acid to tetrahydrofolic acid followed by methylation and diastereoselective crystallization (in water) of L-5-methyltetrahydrofolic acid as its calcium salt. The product contains variable amounts of water of crystallization.
What’s the difference between Crystalline and amorphous L-5-MTHF Ca?
Crystalline L-5-MTHF Ca could be kept for 2years.
While, the amorphous is very easy to degrade, only could be kept at most 30days.
Amorphous form is easy to degrade,the degradation impurities is harmful to body.
The bioavailability of L-5-MTHF Ca Crystalline would be around 2-3times higher than the L-5-MTHF Ca amorphous.
Crystalline form had been registered in US.FDA/NDI, GRAS,etc.
While, the amorphous didn’t be registered yet.