Folic acid from the pteridine, p-aminobenzoic acid and L-glutamic acid composition, also known as phylin glutamate, it is a B vitamins. It was found after being named: Vitamin M, Vitamin Bc, R Factor, etc. In 1941, because of the discovery of this biological factor from spinach, it was named folic acid. Folic acid is rich in fresh fruits, vegetables, meat products. Foliage in food if the long cooking time, can be lost 50% to 90%. Folic acid is mainly absorbed in the duodenum and proximal jejunum. Human folic acid storage capacity of 5 ~ 20mg. Folic acid is mainly excreted by urine and feces in vitro, the daily discharge of 2 ~ 5ug.
Classification of folic acid
Natural folic acid: natural folic acid is widely found in animal and plant foods, especially in yeast, liver and green leafy vegetables are more content.
Synthetic folic acid: folic acid containing a lot of food, but because of the natural folic acid is very unstable, susceptible to sunlight, the impact of heating and oxidation, so the human body can really get from the food folic acid is not much. Folic acid bioavailability is low, at about 45%. Synthetic folic acid in a few months or years can be stable, easy to absorb and high human use, about twice as high as natural products. Folic acid from the beginning of the extraction of liver extract, the use of synthetic production. Folic acid traditional synthetic route is nitrobenzoic acid as raw material by acid chlorination, condensation, reduction, cyclization. This process is long, low yield, high production costs. The use of tetramethoxypropanol and p-aminobenzoyl-L-glutamic acid as the main raw material and triaminopyrimidine sulfate reaction to produce folic acid, the total yield of 75%, 98% purity.
When folic acid is eaten
Continued throughout pregnancy. Because the level of folic acid in women, not after treatment can rise in the short term.
In pregnancy, late, baby DNA synthesis, placenta, maternal tissue and erythrocyte increase have increased your demand for folic acid. So even if the baby's nervous system in the early pregnancy has been developed, but the pregnancy, the late folic acid deficiency will still cause megaloblastic anemia, preeclampsia, placental abruption occurred.