MAGNAFOLATE® ---Prevent Nervous system diseases
Folate is an essential substance in the synthesis and metabolism of monoamine neurotransmitters(5-serotonin,epinephrine, dopamine).
6S-5- leucovorin can pass through the blood-brain barrier, acting on the brain tissue, releasing neurotransmitters, such as dopamine, norepinephrine, and five hydroxy amines, etc., to ensure the smooth passage of the brain nerve signals
Epidemiological studies and case studies show that low levels of folate in the blood are associated with poor cognitive function, dementia and Alzheimer's disease. In the course of neurotransmitter synthesis, folate, especially 6S-5-methyltetrahydrofolate is particularly important for emotion and cognition
6S-5- methyltrahydrofolate is an active form of folate metabolism. It play a tremendous role in the process of amino acids remethylation to Hey, methionine production.
Antidepressant effects can be achieved by enhancing the release of the brain's antidepressant transmitter.
Studies have shown that up to 70% of severe depressive patients suffer from MTHFR, C677T folate gene metabolism disorder.
This metabolic disorder lowers the body's ability to transfer folate to methylfolate, which leads to the neurotransmitter can’t be delivered effectively thus causing depression.
That is, low folate levels are associated with depression. Most depression can get good results with the amount of folate intake.
Hence,Magnafolate ® could be used for the prevention and adjuvant treatment of Nervous system diseases.