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Magnafolate®
About US
Knowledge of L-methylfolate
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History & Regulatory Status

History
Regulatory

- 1943

-A scientist Dr.Mitchell from USA extracted around 1mg active folate from four tons of spinach successfully in 1943. However, the chemical property is too active to be stored.

-“How to make the active folate be stable?” has been a global difficulty since 1943.

- 1945

-Folic acid was developed.

-It was a great invention at that time because it's stable enough.
But it's not the best choice with more and more side effects are reported nowdays.

- 1965

-Merck developed 5-methyltetrahydrofolate calcium racemate . CAS.134-35-0

-Racemate is mixed both levorotatory-5-MTHF(what we really need) and Dextral-5-MTHF. D-5-MTHF is not workable.

- 1994

-Merck developed a Pure levorotatory-5-methyltetrahydrofolate calcium Amorphous type. CAS.151533-22-1

-The potency is twicer than racemate 5-MTHF Ca ,but it's still not stable.

- 1999

-Merck developed I crystalline Metafolin® CAS.151533-22-1

-The preparation of the Calcium salt and the crystal type solved the stability problem completely.

- 2012

-Jinkang pharma developed a novel C crystalline Calcium L-5-Methyltetrahydrofolate, called “Magnafolate®” successfully, CAS.151533-22-1

-It's a totally new crystal type independent from Merck's Metafolin®. More uniform and narrow particle size distribution and higher bioavability than Metafolin®.

- 2022

-Jinkang finished the study between Folic acid and Magnafolate® PRO in birth defect

-The paper has been published, if interested, email us info@magnafolate.com

Since L-Methylfolate came out, it has been recognized by various laws and regulations.

- 2001

-The US FDA approved the application of 6S- 5-methyltetrahydrofolate calcium as a new raw material in Nutrition and Health Care Products.

- 2004

-The European Food Safety Authority (EFSA) concluded that 6S-5-methyltetrahydrofolate calcium is safe with the use range of 1 mg / day.

- 2005

-JECFA confirmed 6S-5-methyltetrahydrofolate calcium is safe as folate source.

- 2006

-EU Commission published 2006/34/EC and 2006/37/EC with L-methylfolate

- 2007

-L-methylfolate approved in Switzerland and Norway

- 2009

-Approved in Canada for use in dietary supplements

- 2015

-TGA approval for L-methylfolate in Australia

- 2017

-China National Health and Family Planning Commission approved Magnafolate®6S-5-methyltetrahydrofolate calcium as folate source, used in food supplement.
-Magnafolate® PRO is quality standard in China

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Latest News

How to Get Enough Calcium L-5-Methyltetrahydrofolate (Active Folate)

How to Get Enough Calcium L-5-Methyltetrahydrofolate (Active Folate)

What's the harm of folate deficiency-Magnafolate

What's the harm of folate deficiency-Magnafolate

Discover the Magic of Calcium L-5-Methyltetrahydrofolate: The Secret to Improved Physical and Mental Health

Discover the Magic of Calcium L-5-Methyltetrahydrofolate: The Secret to Improved Physical and Mental Health

© 2021 Lianyungang Jinkang Hexin Pharmaceutical Co.,Ltd. - All Rights Reserved jinkang-chem

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