·   Magnafolate® no need metabolism, can be absorbed directly


while food folate and folic acid need to undergo several biochemical conversions in the body to become L-5-MTHF.

·   What is MTHFR 677 TT gene mutation?


References: Moll S, Varga EA. Homocysteine and MTHFR Mutations. Circulation. 2015;132(1):e6-9.
Global variation in MTHFR 677 Genotypes is in Figure1

·   Global MTHFR polymorphism distribution


Over 30% of the global population has a genetic mutation to MTHFR, specifically C677T, that doesn’t allow their bodies to convert folic acid to active folate (L-5-MTHF). This means the only way to supplement folate is with L-5-MTHF as it is the exact form the body needs, and it bypasses the genetic mutation. Countries with the highest distribution of C677T are Chile, China, Italy, & Mexico.


·   MTHFR polymorphism complications


When the maternal MTHFR gene is 677 TT:
· 5.9 times more likely to have children with cleft lip and palate
· 2.6 times more likely to have children with Down Syndrome
· 2 times more likely to have babies with neural tube defects
· 1.2 times more likely to have children with congenital heart disease

·   Potential Dangers of Folic Acid


Folate is absorbed in the gut while Folic Acid is absorbed in the Liver
The Liver is easily saturated and can lead to unmetabolized Folic Acid in the bloodstream Unabsorbed Folic Acid in the blood, can cause health problems for people treated for leukemia, arthritis, abnormal pregnancy, men with a family history of bowel cancer, clogged arteries, and vitamin B deficiency
The possible harmful effects of unabsorbed Folic Acid on the human body will take 20 years to manifest
Ask comparision report between Magnafolate® and Folic acid, follow us or email directly to [email protected]

·   Quick Summary

Acute toxicity
N/A
LD50 10mg/kg
LD50 2000mg/kg
MTD>15g/kg
Cover up the use of VB12 ?
No
Yes
No
No
Can it across into the brain?
Yes
NO
Yes
Yes
Absorption site
Through the intestinal absorption,
do not need to go through the liver, the dosage is unlimited
Liver, the dosage is limited
Through the intestinal absorption,
do not need to go through the liver, the dosage is unlimited
Through the intestinal absorption,
do not need to go through the liver, the dosage is unlimited
Absorption and utilization
After hydrolysis
Need three step enzyme catalysis
Directly
Genetic abnormality
Effective
Inefficient
Effective
Source
Difficult to obtain
The easiest to obtain
Easy to obtain
Cost
High cost
The lowest cost
Lower cost
Chemical stability
Extreme unstable
Stable
Stable
Reducibility
Strong
N/A
Strong
Dosage
High limit
High limit
Low limit
Side effect
N/A
Causes a decrease in immunity multiple births, leukemia, arthritis, and certain diseases that have not yet been found
N/A
Effects on the liver
Protects the liver by protecting GSH activity, but is less affected by fewer amounts
Increase liver burden
Protects liver by protecting GSH activity
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