Folic acid, which is widely used for food
fortification and as an ingredient in dietary supplements, is the precursor of L-5-MTHF.
L-5-MTHF-Ca is intended for use in dry crystalline or microencapsulated form as an alternative to folic acid in foods,including dietary supplements.

L-5-MTHF-Ca is a white to light yellowish, almost odourless, water-soluble crystalline powder. It is obtained by reduction of synthetic folic acid with sodium borohydride, condensation of the resulting tetrahydrofolic acid with formaldehyde, further reduction of the 5,10-MTHF with NaBH4
to L-5-MTHF,and finally crystallization as the calcium salt.
Crystalline L-5-MTHF-Ca is stable on storage after micronizing,and when compounded into vitamin and mineral tablets. It appears to be better suited than folic acid for the vitamin enrichment of foods.
Tests with L-5-MTHF-Ca have shown that L-5-MTHF has a similar or slightly higher bioavailability and bioefficacy than folic acid.

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