Improved Stability of a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt, 

Method Development and Validation of an LC–MS/MS Method for Rat Pharmacokinetic Comparison

We are honored to publish an article about calcium 6s-5-methyltetrahydrofolate of crystal form C in the international journal PubMed, which was finally unanimously reviewed by the international authoritative expert group. 

The conclusions are as follows:
a novel crystal form C of 6S-5-methyltetrahydrofolate calcium salt might be a good supplement to folate.

Article Abstract
Folate is a vitamin beneficial for humans that plays an important role in metabolism, but it cannot be well supplemented by food; it is necessary to supplement it in other ways. Based on this consideration, a novel crystal form C of 6S-5-methyltetrahydrofolate calcium salt (MTHF CAC) was obtained. To explore the difference between MTHF CAC and the crystal form Ⅰ of 6S-5-methyltetrahydrofolate calcium salt (MTHF CA) as well as an amorphous product of 6S-5-methyltetrahydrofolate glucosamine salt (MTHF GA), their stability and pharmacokinetic behaviours were compared. 

Lian Z, Chen H, Liu K, Jia Q, Qiu F, Cheng Y. 
Improved Stability of a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt, Method Development and Validation of an LC-MS/MS Method for Rat Pharmacokinetic Comparison. 
Molecules. 2021 Oct 3;26(19):6011. 
doi: 10.3390/molecules26196011. PMID: 34641555; PMCID: PMC8512888.

If you are interested, Please click here to read the full-text：
https://pubmed.ncbi.nlm.nih.gov/34641555/