One of the most common mutations to MTHFR is C677T. People with this variant have less activity of an enzyme that breaks down homocysteine. They may have high levels of homocysteine, which could increase their heart disease risk.
In a pregnant person, this variant can also increase the chance of neural tube irregularities in a developing fetus
Having an MTHFR mutation alone doesn’t mean you’re at risk of health problems or that you need treatment. But if your homocysteine levels are high, a healthcare professional may recommend that you take folate supplement.

We recommend you to supplement better folate:
Magnafolate® L Methylfolate(active folate)—maximizes the supplementation delivering a "finished" folate the body can immediately use without any kind of metabolization.
It can better supplement the folate that the body lacks.
Jinkang Pharma ,the Manufacturer & Supplier of L Methylfolate.