For folate to be active, it needs to have 5,l0-methylenetetrahydrofolate depicted by the MTHFR as 5-methyltetrahydrofolate.

People with the 677TT genotype have reduced MTHFR activity and ingested folate cannot be converted to active folate. In this group, an additional intake of 5-methylenetetrahydrofolate is required under supervision to ensure that Hcy can successfully complete the methionine cycle and to reduce the level of Hcy in the blood.
Magnafolate L Methylfolate raw material
Magnafolate L Methylfolate ingredient

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