At present, the main form of folate supplementation is synthetic folic acid (FA), but its excessive supplementation will increase the potential risk of some diseases for oneself and offspring.

5-methyltetrahydrofolate, also known as L-5-methyltetrahydrofolate, is the main natural form, which is more conducive to human absorption and utilization. Compared with synthetic folic acid FA, 5-methyltetrahydrofolate has no upper tolerance limit, which can be directly absorbed and utilized by the body to reduce the burden on the body.