
The main metabolic history of inactive synthetic folic acid in the body is as follows: during absorption in the intestine and during transport to peripheral tissues, synthetic folic acid is reduced by dihydrofolate reductase to dihydrofolate; dihydrofolate continues to be reduced by dihydrofolate reductase to tetrahydrofolate: tetrahydrofolate is then converted to 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate is finally reduced by methylenetetrahydrofolate 5,10-methylenetetrahydrofolate is finally catalyzed by methylenetetrahydrofolate reductase (MTHFR) to form L-5-methyltetrahydrofolate, which is involved in two key metabolic pathways: methylation processes and DNA synthesis. It is through these metabolic processes that inactive synthetic folic acid is converted into biologically active 5-methyltetrahydrofolate.

Therefore we recommend calcium L-5-methyltetrahydrofolate:
Magnafolate is the unique patent protected C crystalline L-5-Methyltetrahydrofolate Calcium salt (L-5-MTHF Ca) which can get the purest and most stable bio-active folate.
Magnafolate can be absorbed directly, no metabolism, applied for all people.