During the pre-conception and pregnancy period, every expectant mother hopes to provide the most premium nutrition for her baby, and folic acid is undoubtedly one of the key nutrients. However, for many infertile families, relying solely on ordinary folic acid supplementation may not be sufficient. 

In recent years, a novel study in the field of reproductive medicine has revealed that a special type of folate—active folate, namely 5-methyltetrahydrofolate, when combined with vitamin B12 supplementation, can significantly enhance the clinical pregnancy rate and live birth rate for women undergoing assisted reproductive technology (ART). The rate is even 83% higher than that of non-active synthetic folic acid. This discovery brings new hope to the journey of conception and offers a new direction for the choice of folate supplementation.

Research Findings: The Significant Advantages of 5-Methyltetrahydrofolate and B12 Complex Vitamins

For numerous infertile families, assisted reproductive technology (ART) serves as a crucial pathway to fulfilling their dreams of having a child. Yet, the success rate has always been a focal point of attention. A recent study indicates that supplementing with a complex of 5-methyltetrahydrofolate and B12 vitamins may offer higher clinical pregnancy and live birth rates for women undergoing ART. This finding undoubtedly sheds new light on women striving to conceive.

The research employed a retrospective study method, enrolling 269 Caucasian women who visited an ART center for assisted reproduction. Among them, 111 women supplemented daily with a complex of 5-methyltetrahydrofolate and B12 vitamins, while the remaining 158 women only supplemented with ordinary synthetic folic acid.

The study demonstrated that, compared to women who only supplemented with synthetic folic acid, those who supplemented with the 5-methyltetrahydrofolate and B12 complex exhibited significant advantages in the ART process.

Specifically, the average number of metaphase II (MⅡ) oocytes (2PN refers to the state of oocytes under a microscope after fertilization, showing two pronuclei. This is a key indicator for determining successful fertilization) was 5.7±3.2, higher than the 4.9±4.1 in the synthetic folic acid group (p=0.04), indicating a more ideal stage of oocyte maturation.

Meanwhile, the 2PN fertilization rate (a higher 2PN fertilization rate signifies a smooth fertilization process, higher quality of fertilized eggs, and in turn, greater potential for embryo development and pregnancy success) was 74.1%, surpassing the 63.5% in the synthetic folic acid group (p=0.05), highlighting an improvement in fertilization success rates.

Additionally, among women supplemented with the 5-methyltetrahydrofolate and B12 complex, the clinical pregnancy rate reached 60.4%, and the live birth rate was 48.6%. In contrast, the synthetic folic acid group had corresponding rates of 44.9% and 35.4%.

After multivariable adjustment, the group supplemented with the 5-methyltetrahydrofolate and B12 complex still showed an independent correlation with clinical pregnancy (OR 2.03, p=0.008) and live birth (OR 1.83, p=0.03).

These data strongly suggest that supplementing with the 5-methyltetrahydrofolate and B12 complex may be a significant boost to improving pregnancy success rates for women undergoing ART.

Magnafolate: The Folic Acid More Suitable for Expectant Mothers

As a premium brand of 5-methyltetrahydrofolate, Magnafolate stands out for its exceptional quality. Developed by Lianyungang Jin Kang He Xin Pharmaceuticals Co., Ltd., Magnafolate is a naturalized folic acid with a unique C crystal structure. It not only boasts high stability and fast dissolution but also offers higher bioavailability. Compared to traditional synthetic folic acid, Magnafolate is not restricted by folic acid metabolic enzymes and can be directly absorbed by the body, making it more suitable for individuals of different genders, ages, and ethnicities.

Choose Magnafolate, Choose a Healthy Future

In the journey of conception, every choice matters for the future. Choosing Magnafolate means opting for a safer and more efficient nutritional supplementation method. It is not only grounded in solid scientific research but also carries the expectations of countless families for new life. As the representative of naturalized folic acid, Magnafolate, with its superior quality and broad application, is bringing hope and happiness to more families. Let us welcome the arrival of new life and create the best beginning for every little life with science and love. Magnafolate, safeguarding your journey to conception.

Reference：Michela Cirillo, Rossella Fucci, Sara Rubini, Maria Elisabetta Coccia, & Cinzia Fatini. (2020). 5-Methyllumetetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology. International Journal of Environmental Research and Public Health, 17(21), 7890. https://doi.org/10.3390/ijerph17217890