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Several factors affecting folate status The World Health Organization (who) has also reported that many factors affect folate status, including genetics, such as MTHFR gene polymorphism. Other factors include physiological status (such as age, pregnancy, lactation); Biological factors (e.g., coexisting vitamin B6 and B12 status, homocysteine levels); Background factors (e.g., comorbidity); Moreover, the source of dietary folate is limited.
The L-methylfolate for pregnancy Every year, there are an estimated more than 260,100 pregnancies affected by NTDs worldwide. 5 The prevalence of folate deficiency exceeds 20% in many lower-income economies, and is often below 5% in higher-income economies.
L-Methylfolate VS folate Because the body cannot produce folate, people rely on diet to achieve the levels required for optimal health, especially during pregnancy. However, folate is a general term used to identify a wide range of water-soluble B vitamins, including reduced folate naturally present in foods, and oxidative synthetic folate in supplements and fortified foods. In order to create better folate based pregnancy products, it is important to understand the correct type of folate required.
What is MTHFR and the effects of its absence Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that breaks down the amino acid homocysteine. The MTHFR gene that codes for this enzyme has the potential to mutate, which can either interfere with the enzyme’s ability to function normally or completely inactivate it.
The importance of L-Methylfolate for body L-Methylfolate is important for a range of functions in the body. It helps the body make healthy new red blood cells, for example. Red blood cells carry oxygen throughout the body. If the body does not make enough of these, a person can develop anemia, leading to fatigue, weakness, and a pale complexion.
Daily supplement of folate recommended to prevent birth defects The Centers for Disease Control and Prevention (CDC) report that birth defects affect approximately 3 percentTrusted Source of babies born each year in the United States, and they are the leading cause of death among infants.
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