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The importance of L-5-Methyltetrahydrofolate
Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.* A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects, which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, epinephrine, and norepinephrine, supplementation supports healthy mood.
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What Studies Have Shown about 5-MTHF?
What Studies Have Shown about 5-MTHF? Many studies have been conducted over the years comparing supplementation of 5-MTHF with that of folic acid and the two main advantages (of 5-MTHF) that have been found are...
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What Does L-5-methylfolate Do
What Does L-5-methylfolate Do? L-5-methylfolate (together with vitamin B12) functions as a methyl group donor in a range of metabolic and nervous system processes, making it vital to numerous metabolic pathways in the body. L-5-methylfolate plays an essential role in methylation, it enables the conversion of homocysteine to methionine, the production of serotonin and melatonin, and it is indirectly involved in the synthesis of DNA.
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What is MTHFR?
MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in the process of folate metabolism, which can catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), as an indirect donor of methyl groups, then participate in the synthesis of purines and pyrimidines and the methylation of DNA, RNA, and proteins in the body, maintaining normal homocysteine levels in the body.
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Is it necessary to take supplements containing methylfolate rather than folic acid?
The answer is “YES”. Around 30% people have the MTHFR gene defect globally, folic acid can’t be absorbed by these people. So, it is necessary to them to use methylfolate which don’t need metabolism and can be adsorbed directly.
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Why should you choose methylfolate with crystal form?
Have you heard of crystalline vs. amorphous types? Most of us don’t know the difference between the two, but in the biochemistry world, it makes a really BIG difference to stability.
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