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Does the form of folate matter?
Does the form of folate matter? The short answer: Yes. Folic acid is the form used in many supplements because it’s highly stable. The caveat? Once folic acid enters a cell, it needs to be converted into 6S-5-Methyltetrahydrofolate (MTHF) by several key enzymes before your body can use it. And up to one-third of men and women have a genetic variation that can impact the last step of the conversion.
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How should we get right folate?
How should we get right folate? The best dietary sources of natural folate include fresh fruits, leafy greens, yeast, and legumes, but these can easily be degraded during food prep and cooking; this means that those foods often become less nutritious sources of folate as soon as they’re manipulated, i.e. chopped or cooked.
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Which isomers are present in the nutrient? Is L or (6S) best? What about (6S)+(6R) or DL?
Methylfolate can be quickly manufactured as a material that has both the 6S and 6R isomers (or L and D respectively).
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Why is folate important?
Why is folate important? Folate is an essential nutrient best known for supporting neural tube development during pregnancy. But for everyone else, folate is still a must-have. It’s involved in multiple processes, including DNA methtylation.
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The importance of L-5-Methyltetrahydrofolate
Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.* A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects, which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, epinephrine, and norepinephrine, supplementation supports healthy mood.
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What Studies Have Shown about 5-MTHF?
What Studies Have Shown about 5-MTHF? Many studies have been conducted over the years comparing supplementation of 5-MTHF with that of folic acid and the two main advantages (of 5-MTHF) that have been found are...
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