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Clinical application of MTHFR gene polymorphism detection
Infertility outpatient reproductive center Decreased men's sperm density, recurrent abortion, etiological diagnosis of complex diseases. The MTHFR C677T genotype increased the risk of male infertility by 2.68 times, and the TT genotype had a 2.96 times higher risk of habitual abortion than the wild type.
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MTHFR gene & neuropsychiatric diseases
Methylenetetrahydrofolate reductase (MTHFR) is one of the key enzymes in the metabolism of folate and homocysteine (Hcy), and is involved in the occurrence of neuropsychiatric diseases such as Alzheimer's disease and depression.
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How does MTHFR gene affact us?
MTHFR genetic defects will affect the body's use of folic acid, causing pregnancy-induced hypertension, spontaneous abortion, fetal neural tube defects, congenital heart disease, cleft lip and palate, etc. Insufficient amount of effectively used folate can lead to birth defects and adverse pregnancy outcomes, but is also a high-risk factor for infant intellectual development, maternal depression, and child autism.
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MTHFR genotype causes abnormality of folate metabolism and related disease mechanism
MTHFR genotype causes abnormality of folate metabolism and related disease mechanism
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Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy?
North American health authorities recommend 0.4 mg/day folic acid before conception and throughout pregnancy to reduce the risk of neural tube defects. As usual, there are folic acid and L-Methylfolate for pregnants.
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Low folate status is associated with mild cognitive impairment, dementia (particularly Alzheimer’s disease)
Actually, in almost all tissues, including the brain, folates are required for one-carbon transfer reactions, which are essential for the synthesis of DNA and RNA nucleotides, the metabolism of amino acids and the occurrence of methylation reactions.
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Clinical application of MTHFR gene polymorphism detection

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MTHFR gene & neuropsychiatric diseases

Learn More

How does MTHFR gene affact us?

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MTHFR genotype causes abnormality of folate metabolism and related disease mechanism

Learn More

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy?

Learn More

Low folate status is associated with mild cognitive impairment, dementia (particularly Alzheimer’s disease)

Learn More

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