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There is widespread agreement that maintaining adequate folate status is critical to prevent diseases due to folate inadequacy (e.g., anemia, birth defects, and cancer). However, there are concerns of potential adverse effects of excess folic acid intake and/or elevated folate status, with the original concern focused on exacerbation of clinical effects of vitamin B-12 deficiency and its role in neurocognitive health. More recently, animal and observational studies have suggested potential adverse effects on cancer risk, birth outcomes, and other diseases.
Daily 266mcg folic acid intake is disrupting our normal folate metabolism Actually, DHFR enzyme plays an important role during folate metabolism. The function of DHFR is to decompose natural folate and synthetic folic acid into active folate (5-MTHF) . DHFR acts quickly on natural folate, but slowly on folic acid. It can only metabolize about 266 mcg folic acid per day. Taking folic acid more than 266mcg, the Unmetabolized folic acid(UMFA) will build up in our body.
What our body really need is L-5-MTHF( L-5-Methyltetrahydrofolate ). But we can’t absorb it directly. Later, scientist made it into salt form. When we eat salt L-5-MTHF, it will be dissolved into Ionic form and be absorbed by ionic channel in our body. The most popular salt form is Calcium salt.
L-methylfolate can be used for people who have conditions related to folate deficiency.
Unlike folic acid, Magnafolate® will not mask vitamin B12-deficiency.Many people have genetic MTHFR variations, while Magnafolate® can be absorbed directly.Magnafolate® can cross the blood-brain barrier, adjust the cognitive. Magnafolate® can lower elevated homocysteine levels.
Folate is particularly critical for the development of the fetus's nervous system. Pregnant women can prevent the occurrence of fetal neural tube defects by supplementing with folate in an appropriate amount. Moreover, pregnant women’s demand for folate is four times higher than that of normal people. If the intake of folic acid is insufficient, it will cause anemia, affect DNA synthesis and repair, and adversely affect health.
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