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For almost 20 years, we have become the most professional manufacturer in the world, No.1 in China in the methylfolate industry. With strict quality guarantee system, strong brand awareness and high-level after sale service, our company is famous for the business philosophy “Only manufacture and supply premium quality products.”
MTHFR genetic defects will affect the body's use of folic acid, causing pregnancy-induced hypertension, spontaneous abortion, fetal neural tube defects, congenital heart disease, cleft lip and palate, etc. Insufficient amount of effectively used folate can lead to birth defects and adverse pregnancy outcomes, but is also a high-risk factor for infant intellectual development, maternal depression, and child autism.
MTHFR genotype causes abnormality of folate metabolism and related disease mechanism
North American health authorities recommend 0.4 mg/day folic acid before conception and throughout pregnancy to reduce the risk of neural tube defects. As usual, there are folic acid and L-Methylfolate for pregnants.
Actually, in almost all tissues, including the brain, folates are required for one-carbon transfer reactions, which are essential for the synthesis of DNA and RNA nucleotides, the metabolism of amino acids and the occurrence of methylation reactions.
A crystalline salt form is a key requirement for a satisfactory stability in capsules or tablets, so Magnafolate® is less likely to lose its potency over time.
The term "folate" is actually a generic name for a group of related compounds with similar nutritional properties. The three most commonly used forms are folic acid, calcium folinate and levomefolate salts. All three forms can be incorporated into the body's metabolic pathways and may provide sources of the same biologically active form of folate – a compound known as 5-methyltetrahydrofolate (5-MTHF) or levomefolic acid.
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