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What does it mean if you have the MTHFR gene? Certain gene changes affect how your body uses folate. Methylenetetrahydrofolate reductase (MTHFR) is an enzyme that breaks down homocysteine. Changes called mutations in the code for MTHFR can affect your health by changing folate levels in your body.
What does MTHFR gene affect? When you take folic acid, your liver has to convert it into the active form, 5-methyltetrahydrofolate (5-MTHF). If your liver doesn’t convert it quickly enough, folic acid can build up in your blood. Eating foods containing 5-MTHF instead of folic acid can prevent this from happening.
Folate/Folic Acid Helps Reduce Heart Disease Risk Folate/Folic Acid based supplements, may help improve heart health and reduce the risk of heart disease.
Preventing birth defects and pregnancy complications Folate/Folic acid supplements can help to prevent neural tube irregularities, including spina bifida and anencephaly. Getting enough Folate/Folic acid during pregnancy can reduce the chance that your baby will be born with one of these conditions.
Folate benefits mental health Folate is involved in the production of brain chemicals called neurotransmitters. Too little folate intake is associated with depression, schizophrenia and other mental health conditions. For example, people with depression may have lower blood folate levels than people without depression.
Folate and L-Methylfolate for Brain Health Low blood folate levels are linked to poor mental function and an increased risk of dementia. Even folate levels that are technically normal but on the low side might increase the risk of mental impairment in older adults.
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