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What is MTHFR?
MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in the process of folate metabolism, which can catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), as an indirect donor of methyl groups, then participate in the synthesis of purines and pyrimidines and the methylation of DNA, RNA, and proteins in the body, maintaining normal homocysteine levels in the body.
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Is it necessary to take supplements containing methylfolate rather than folic acid?
The answer is “YES”. Around 30% people have the MTHFR gene defect globally, folic acid can’t be absorbed by these people. So, it is necessary to them to use methylfolate which don’t need metabolism and can be adsorbed directly.
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Why should you choose methylfolate with crystal form?
Have you heard of crystalline vs. amorphous types? Most of us don’t know the difference between the two, but in the biochemistry world, it makes a really BIG difference to stability.
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What is L-Methylfolate (5-MTHF)
What is L-Methylfolate (5-MTHF)? L-methylfolate is the biologically active form of vitamin B9. That means it is the form the human body can actually use in circulation.
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L-5-Methylfolate:May Reduce Stroke & Heart Attack Risk
L-5-Methylfolate:May Reduce Stroke & Heart Attack Risk L-5-Methylfolate could improve heart and circulatory health by reducing homocysteine and through other mechanisms. However, it’s complicated. It might only reduce your risk of heart attack or stroke if you’re folate deficient.
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a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt
Folate is a vitamin beneficial for humans that plays an important role in metabolism, but it cannot be well supplemented by food; it is necessary to supplement it in other ways. Based on this consideration, a novel crystal form C of 6S-5-methyltetrahydrofolate calcium salt (MTHF CAC) was obtained. To explore the difference between MTHF CAC and the crystal form Ⅰ of 6S-5-methyltetrahydrofolate calcium salt (MTHF CA) as well as an amorphous product of 6S-5-methyltetrahydrofolate glucosamine salt (MTHF GA), their stability and pharmacokinetic behaviours were compared.
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